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What Enzymes oxidize cell substances?
Enzymes like catalase, cytochrome P450, and alcohol dehydrogenase are involved in oxidizing cell substances. Catalase breaks down hydrogen peroxide, cytochrome P450 is involved in drug metabolism, and alcohol dehydrogenase metabolizes ethanol.
How does phenobarbital undergo phase 1 metabolism?
Cytochrome P450 allows phenobarbitual to undergo aliphatic hydroxylation. It then turns into an alcohol.
Which of the following drugs inhibits the cytochrome P450 system?
Cimetidine
How does diazepam undergo phase 1 metabolism?
Cytochrome P450 allows phenytoin to undergo aromatic hydroxylation to turn into phenol.
Does halothane induce cytochrome p450?
Yes. There is scientific evidence to indicate that Halothane is able to induce cytochrome P450. P450 in turn anaerobically reduces halothane to potentially toxic metabolic compounds that cause liver damage
How many cytochrome P450 are there in the body?
There are over 50 different cytochrome P450 enzymes in the human body, each with specific roles in metabolizing various substances including drugs, toxins, and endogenous compounds.
What is the clinical importance of cytochrome P450?
The human cytochrome P450 comprises 57 genes. These genes code for enzymes that can have a role in: metabolism of drugs, foreign chemicals, cholesterol metabolism and more. P450 was once thought to be mainly a hepatic drug detoxication system, its now believed to include a myriad of enzymic reactions implicated in important life processes.
How does amphetamine undergo phase 1 metabolism?
Cytochrome P450 allows amphetamine to undergo oxidative deamination.
What has the author Karen Grierson written?
Karen Grierson has written: 'Role of the inducible cytochrome P450 isoenzymes in the metabolism of melatonin'
What has the author Kathryn Elizabeth Brocken written?
Kathryn Elizabeth Brocken has written: 'Cytochrome P450 isoenzyme activities in dog'
How is alcohol removed from the body?
Alcohol is mostly metabolized by the liver into acetaldehyde and then into acetate, which is eventually eliminated from the body as carbon dioxide and water. The process primarily involves liver enzymes such as alcohol dehydrogenase and cytochrome P450. Some alcohol can also be excreted unchanged through breath, sweat, urine, and saliva.
How does codeine undergo phase 1 metabolism?
Cytochrome P450 and CYP2D6 allow codeine to undergo O-demethylation to form morphine.
