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Oven mitts would never be made from a poisonous substance, that would be ridiculous, but since they are intended to be highly heat resistant, there could oven mitts that contain asbestos, and while asbestos is not actually poisonous, asbestos fibers are a serious irritant if they are inhaled, and may result in lung cancer, which is why the use of asbestos for most purposes has been greatly limited and reduced (it's still a very useful additive for making stronger cement).

Should the oven mitt be contaminated by a poison, then yes one could be poisoned by that mitt

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Q: Can you get poisoned by oven mitts?
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