NON-ROUTABLE PROTOCOLS cannot survive being routed. Non-routable protocols presume that allcomputers they will ever communicate with are on the same network (to get them working in a routed environment, you must bridge the networks). Todays modern networks are not very tolerant of protocols that do not understand the concept of a multi-segment network and most of these protocols are dying or falling out of use.
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An example of a protocol that is not routable is NetBIOS. Another example is DECs LAT protocols. They are not routable because they don't have a network address.