There are many factor that can affect the proper operation of computer.The hardware compatibility is the most important factor and then comes the compatible soft-wares.Temperature and humidity also affect the computer's working .The high temperature would lead to hardware failure.Humidity might lead to statics electricity formation on the the mother boards and other hardware.
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Extreme heat or cold, excessive dirt and dust, ANY LIQUIDS (ie. don't water cool your PC if you don't know what you're doing) , frayed or exposed wires, list goes on and on