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12y ago
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5mo ago

Formaldehyde is used in Mannich base formation as a source of a reactive carbonyl species that can react with an amine and an enolizable compound to form the Mannich base. The formaldehyde provides the carbonyl functional group necessary for the reaction to occur, leading to the formation of aminomethylated compounds with potential pharmaceutical or synthetic applications.

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Q: Why formaldehyde use in mannich base formation?
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