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Methylxanthines inhibit phospodiesterase which is enzyme that degrade cAMP to AMP. Thus lead to an increase in cAMP

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βˆ™ 12y ago
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βˆ™ 9mo ago

Methylxanthines like theophylline work as bronchodilators by inhibiting phosphodiesterase enzymes, particularly phosphodiesterase-4. By blocking these enzymes, methylxanthines prevent the breakdown of cyclic AMP which leads to smooth muscle relaxation in the airways, resulting in bronchodilation and improved airflow.

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Q: What is the mechanism of action of methylxanthine as a bronchodilator?
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What is the meaning of mechanism of action in pharmacology?

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