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Positively charged carbon atom of the aldehyde's carbonyl group attacks p-position of aniline, having a negative charge. Compound 1 forms, with a positive carbon attacking a p-position of another aniline molecule.
NH2-C6H5 + RC(O)H -> NH2-C6H4-CHR(OH) (compound 1)
NH2-C6H4-CHR(OH) + NH2-C6H5 -> NH2-C6H4-CH(R)-C6H4-NH2 + H2O
In case of formaldehyde, the product is 4,4'-methylenedianiline (MDA).
The reaction of aniline with acetic anhydride typically forms the product N-phenylacetamide and acetic acid. The chemical equation for the reaction can be represented as: C6H5NH2 + (CH3CO)2O → C6H5NHC(O)CH3 + CH3COOH.
These compounds undergo a nucleophilic substitution reaction followed by an elimination, to produce an imine.http://www.mhhe.com/physsci/chemistry/carey/student/olc/ch22aldehydeskeytonesamines.html
The reaction mechanism of aniline with acetic anhydride is that it will attack. Aniline readily undergoes an electrophilic mechanism and will instantly react.
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Why add of little amount from acetic anhydride in synthesis of acetanilide?
Adding a small amount of acetic anhydride helps to facilitate the acetylation reaction with aniline, leading to the formation of acetanilide. The acetic anhydride serves as an acetylating agent that transfers an acetyl group to the amine group of aniline, resulting in the desired product. The use of an excess of acetic anhydride is avoided to prevent side reactions and to optimize the yield of acetanilide.
What is the balanced equation for the reaction between salicylic acid and acetic anhydride?
The balanced equation for the reaction between salicylic acid and acetic anhydride to form aspirin (acetylsalicylic acid) is: salicylic acid + acetic anhydride → aspirin + acetic acid.
What is the balance chemical equation of acetic anhydride?
The balanced chemical equation for the reaction involving acetic anhydride (C4H6O3) is: 2C4H6O3 → 4CH3COOH + (CH3CO)2O
What is the role of the acetic anhydride in this reaction in the synthesis of acetanilide?
Acetic anhydride acts as an acetylating agent, adding an acetyl group to the amine group of aniline to form acetanilide. The acetyl group adds functionality to the aniline molecule, making it less basic and more soluble in organic solvents.
Reaction of methyl amine and acetic anhydride?
The reaction between methylamine and acetic anhydride results in the formation of N-methylacetamide as the primary product. In this reaction, acetic anhydride reacts with methylamine to form an amide functional group. This reaction is a common method for the synthesis of amides in organic chemistry.
Why add of little amount from acetic anhydride in synthesis of acetanilide?
Adding a small amount of acetic anhydride helps to facilitate the acetylation reaction with aniline, leading to the formation of acetanilide. The acetic anhydride serves as an acetylating agent that transfers an acetyl group to the amine group of aniline, resulting in the desired product. The use of an excess of acetic anhydride is avoided to prevent side reactions and to optimize the yield of acetanilide.
What is the balanced equation for the reaction between salicylic acid and acetic anhydride?
The balanced equation for the reaction between salicylic acid and acetic anhydride to form aspirin (acetylsalicylic acid) is: salicylic acid + acetic anhydride → aspirin + acetic acid.
What is the balance chemical equation of acetic anhydride?
The balanced chemical equation for the reaction involving acetic anhydride (C4H6O3) is: 2C4H6O3 → 4CH3COOH + (CH3CO)2O
In the aspirin synthesis excess acetic anhydride is hydrolyzed by the addition of water which converts the anhydride into acetic acid Write the balanced equation for this reaction?
The reaction is: (CH3CO)2O + H2O = 2 CH3COOH
What is the role of the acetic anhydride in this reaction in the synthesis of acetanilide?
Acetic anhydride acts as an acetylating agent, adding an acetyl group to the amine group of aniline to form acetanilide. The acetyl group adds functionality to the aniline molecule, making it less basic and more soluble in organic solvents.
What is the alternative route of synthesis of acetanilide?
Acetanilide can also be synthesized by reacting aniline with acetic anhydride, instead of acetyl chloride. This is known as the Acetic Anhydride Method.
What is the reaction when zinc acetic anhydride and glacial acetic acid are combine?
When zinc is reacted with acetic anhydride and glacial acetic acid, a complex called zinc acetate is formed. The reaction typically involves the displacement of acetic anhydride by acetic acid to form zinc acetate. The overall reaction is a redox reaction where zinc is oxidized and acetic anhydride is reduced.
monobromination of acetanilide occurs,while tribromination of aniline would occur under the same conditions?
Write a detailed set of equations for the acetylation reaction, and in particular show clearly that the reaction can be regarded as a nucleophilic substitution, in which the attacking nucleophile is aniline (attacking acetic anhydride).
Reaction of methyl amine and acetic anhydride?
The reaction between methylamine and acetic anhydride results in the formation of N-methylacetamide as the primary product. In this reaction, acetic anhydride reacts with methylamine to form an amide functional group. This reaction is a common method for the synthesis of amides in organic chemistry.
What would happen if the excess acetic anhydride is not removed in the reaction vessel?
If excess acetic anhydride is not removed from the reaction vessel, it can lead to side reactions or undesired byproducts in the final product. It could also affect the purity of the desired compound and make purification more challenging. Additionally, it can pose safety hazards as acetic anhydride is a corrosive and hazardous chemical.
Chemical reaction of hydrolysis of acetic anhydride?
Acetic anhydride undergoes hydrolysis in the presence of water to form acetic acid and a byproduct, typically a carboxylic acid or alcohol. The reaction is a typical nucleophilic acyl substitution reaction, where water acts as a nucleophile attacking the acetic anhydride to break the anhydride bond and form acetic acid.
What reagents may be used for the preparation of acetanilide?
Acetanilide can be prepared using aniline and acetic anhydride as reagents. The reaction typically requires the presence of a catalyst, such as zinc chloride, to facilitate the acetylation of aniline to form acetanilide. The reaction is usually carried out in the presence of a base, like sodium acetate, to neutralize the acidic byproduct formed during the reaction.
