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Calcium ions are inactively imported from the cytoplasm into the ER.

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The endoplasmic reticulum (ER) contains a high concentration of Ca2+ ions due to the presence of specialized pumps (such as SERCA) that actively transport Ca2+ into the ER from the cytoplasm. This accumulation of Ca2+ within the ER is crucial for various cellular functions, including protein folding and lipid synthesis.

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Related questions

What explains the increased concentration of Ca in the ER?

The increased concentration of Ca in the endoplasmic reticulum (ER) can be explained by the presence of specific Ca-ATPases pumps that actively transport Ca ions into the ER. These pumps work against the concentration gradient, using energy from ATP hydrolysis to pump Ca ions into the ER lumen, thereby increasing the concentration of Ca in the ER. This high calcium concentration in the ER is important for various cellular processes, such as protein folding and signaling.


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