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The effects of restorative materials on the dental pulp have been investigated and seem to relate directly to the permeability of the associated dentin. The degree of dentin permeability, however, is often variable and is governed by several factors including age and caries status. As noted before with respect to restorative procedures and bacterial ingress, perhaps the most important variable in dentin permeability to restorative materials is the thickness of dentin between the floor of the cavity preparation and the pulp.Unbound components of resin materials and preparative agents such as acid etchants can affect the subjacent pulp by inducing an inflammatory response.The indirect effects of desiccation and/or demineralization of dentin, as well as direct effects of the material itself when in contact with pulpal tissue, mediate this inflammatory response. Studies have shown that certain cytotoxic components of resin monomers

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