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they inactivate the acetylcholinesterase enzyme which is necessary to break up Ach into acetate and choline,thereby causing increase in synaptic Ach leading to anticholinesterase poisoning...example neostigmine,physostigmine,edrophonium, etc

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12y ago
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7mo ago

Carbamate poisoning occurs when carbamate compounds inhibit acetylcholinesterase, an enzyme that degrades the neurotransmitter acetylcholine. By blocking this enzyme, carbamates lead to an accumulation of acetylcholine at nerve endings, causing overstimulation of cholinergic receptors and leading to symptoms such as excessive salivation, sweating, gastrointestinal disturbances, and muscle tremors.

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Q: Mechanism of action of carbamate poisoning?
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