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A lot of selectivity in any protein is often do to charges of particular amino acid residues. Aquaporin will let through H2O which has a 0 charge, but H+ ions are charged and won't pass through them.

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Aquaporins are water channels that selectively allow the passage of water molecules while blocking the passage of ions, including H+ ions, due to their specific structure and size. The aquaporin's narrow pore does not allow ions to pass through easily, preventing them from moving across the membrane.

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Q: How does the aquaporin prevent h plus ions from passing through?
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