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Why is a frameshift mutation more damaging than a substitution?

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Updated: 6/15/2024

why is frameshift mutation more damanging than a substitution

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A frameshift mutation alters the reading frame of the genetic code, causing all amino acids downstream of the mutation to be incorrect. This can lead to a nonfunctional or drastically altered protein. A substitution mutation only changes one amino acid, which may have a milder effect on protein function.

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Q: Why is a frameshift mutation more damaging than a substitution?

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Which type of mutation will have the most evolutionary consequence?

A frameshift mutation that alters the reading frame of a gene will typically have more evolutionary consequences compared to other types of mutations. This is because it can completely change the amino acid sequence of the resulting protein, leading to significant functional changes that may impact an organism's survival and reproduction.

Which is more harmful frameshift mutation or point mutation?

Frameshift mutations are generally more harmful than point mutations because they can alter the reading frame of the genetic code, leading to a completely different amino acid sequence. This can have a more drastic impact on the resulting protein's structure and function compared to point mutations, which typically only affect a single nucleotide.

What is the impact of a frameshift mutation, where one or more pairs of nucleotides are removed from a gene, on the resulting protein product?

A frameshift mutation, where nucleotides are removed from a gene, can change the reading frame of the gene. This alters the sequence of amino acids in the resulting protein, leading to a non-functional or abnormal protein. This can have serious consequences on the protein's structure and function, potentially causing genetic disorders or diseases.

What are two types of frame shift mutations?

"I believe there is insertion and deletion, (one kind), and substitutions. (the second kind)" This answer is incorrect, the two types of frameshift mutation are insertion and deletion, these both alter the translation reading frame. A substitution point mutation in DNA is referred to as a single-nucleotide polymorphism and does not result in any change to the translational reading frame. insections and deletions are two types of frameshift mutations

9 a DNA segment is changed from -aattagaaatag- to -attagaaatag- this is a?

This mutation represents a deletion of a single nucleotide (A) in the DNA segment. Deletions involve the removal of one or more nucleotides from the DNA sequence, leading to a change in the genetic code. In this case, the deletion results in a frameshift mutation, causing a shift in the reading frame of the genetic code downstream of the deletion site.

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Related Questions

In what type of mutation is one base left out?

A one base left out mutation is called a deletion mutation. This type of mutation involves the loss of one or more nucleotides from a DNA sequence, which can lead to a frameshift mutation if not in multiples of three.

What are types of point mutation?

The types of point mutations are: base-pair substitution, insertions, deletions, and frameshift mutations. In base-pair substitution, one nucleotide and its corresponding partner are replaced with another pair of nucleotide. In insertion, nucleotide pairs are added to a gene. In deletion, nucleotide pairs are taken out of a gene. Frameshift mutation happens as a result of insertion or deletion when more or less than three (or a multiple of three) nucleotide pairs are added to or taken from a gene.

Which type of mutation will have the most evolutionary consequence?

A frameshift mutation that alters the reading frame of a gene will typically have more evolutionary consequences compared to other types of mutations. This is because it can completely change the amino acid sequence of the resulting protein, leading to significant functional changes that may impact an organism's survival and reproduction.

Are point mutations more harmful than frame shift mutations?

It depends on the specific context. Point mutations typically involve a change in a single nucleotide, which may or may not lead to changes in the corresponding amino acid. Frame shift mutations, on the other hand, involve the insertion or deletion of nucleotides that can disrupt the reading frame of the gene, potentially leading to more drastic changes in the resulting protein. So, in general, frame shift mutations could be considered more harmful as they have the potential to alter multiple amino acids downstream of the mutation site.

Which type of mutation will probably have a larger effect A point mutation or a frameshift?

Both types of mutation have the potential to cause a large effect.In general, a frameshift mutation is more likely to cause a large effect. This is because it shifts the 'reading frame' - so that all of the subsequent codons (groupings of 3 bases that are read to determine which amino acid will be added) will be changed.A point mutation is when a single base is replaced. This can either result in the same amino acid being added to the protein being synthesised (a silent mutation), a different amino acid being added (a missense mutation) or in a STOP codon (a nonsense mutation).If a point mutation causes a premature STOP codon - this is quite likely to have a large effect on the protein.

Which is more harmful frameshift mutation or point mutation?

Frameshift mutations are generally more harmful than point mutations because they can alter the reading frame of the genetic code, leading to a completely different amino acid sequence. This can have a more drastic impact on the resulting protein's structure and function compared to point mutations, which typically only affect a single nucleotide.

What is the impact of a frameshift mutation, where one or more pairs of nucleotides are removed from a gene, on the resulting protein product?

A frameshift mutation, where nucleotides are removed from a gene, can change the reading frame of the gene. This alters the sequence of amino acids in the resulting protein, leading to a non-functional or abnormal protein. This can have serious consequences on the protein's structure and function, potentially causing genetic disorders or diseases.

What are two types of frame shift mutations?

"I believe there is insertion and deletion, (one kind), and substitutions. (the second kind)" This answer is incorrect, the two types of frameshift mutation are insertion and deletion, these both alter the translation reading frame. A substitution point mutation in DNA is referred to as a single-nucleotide polymorphism and does not result in any change to the translational reading frame. insections and deletions are two types of frameshift mutations

What is the difference between a point mutation and an insertion and deletion?

A point mutation is a change in a single nucleotide, resulting in a substitution of one base for another. An insertion adds one or more nucleotides to the DNA sequence, while a deletion removes one or more nucleotides. Insertions and deletions can cause frameshift mutations, which can have more drastic effects on the resulting protein sequence than point mutations.

What is the difference between a nonsense mutation and a frame shift mutation?

A point mutation is where a single letter is the only thing changed in the DNA sequence. Lets say your phone number (or DNA code) was 483-1839 and you mistakely told someone that your phone number was 483-1835. that one digit is enough to make that person dial the wrong number (or cause a mutation in DNA.) For example suppose your DNA sequence was ACT GCT, a point mutation would just be a change in one of those bases (or letters), so it could end up something like : ACT ACT.EX: GTA CTG CAA-----> (point mutation) -----> GTA GTG CAAA frameshift mutation is generally much more serious and will cause a change all the way down a DNA sequence, making each codon (or every group of three bases) a different sequence, not just in one point or base like a point mutation, that would only slightly change the sequence of a single codon. A frameshift mutation happens not when a DNA base is simply changed, but when a whole base is added or deleted from the sequence of DNA. For example lets suppose your DNA sequence is GTA CCT AGG. In a frameshift mutation a whole base would be added somewhere in that sequence, making it look something like this: GTAT CCT AGG. Since it is impossible though to have 4 bases in a codon, your body would automatically shift every letter down one, even to the next codon in the sequence, to make room for this new base. In the end the final product would look something like this: GTA TCC TAG (with the left over G being the first base in the next codon, and so on).EX: CAG TTC CTG GAA -----> (frameshift muation) -----> CAG TTA CCT GGAAs you can see the frameshift mutation would leave the mutated DNA vastly more different from its parent DNA (that it was replicated from), then a point mutation would, though in both cases the DNA would still be different/mutated. This is because the codons would be more considerbaly changed with the frameshift (where now the sequence in every codon in different), rather than in a point mutation (where only one of the codons would be different).Hope this helps all you HS Bio 1 people like myself out there, or anyone else studying this subject.-- K.J.S

Where are Kmart corporate offices in Puerto Rico?

A type of genetic mutation in which one or more base pairs are lost: (IS IT REPLACEMENT, SUBSTITUTION, DELETION, INSERTION).

What would happen to translation if a ribosome skipped one or more codons?

If a ribosome skips one or more codons during translation, it can result in a frameshift mutation. This mutation can alter the reading frame of the mRNA sequence, leading to the synthesis of a completely different protein with potentially nonfunctional or altered properties. The severity of the impact depends on where in the mRNA sequence the ribosome skips codons.

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