A mutation within a gene can change the DNA sequence, which can affect the corresponding mRNA sequence. This, in turn, can alter the amino acid sequence of the protein that is produced, potentially changing its structure and function.
Frameshift mutations result in a shift in the reading frame of the genetic code, causing all subsequent codons to be altered. This can lead to the production of a completely different protein with disrupted function. Point mutations, on the other hand, only affect a single nucleotide and may not necessarily change the resulting protein dramatically.
Frameshift mutations are generally more harmful than point mutations because they can alter the reading frame of the genetic code, leading to a completely different amino acid sequence. This can have a more drastic impact on the resulting protein's structure and function compared to point mutations, which typically only affect a single nucleotide.
Amino acids have 2 functional groups, an a-carboxyl group and an-amino group.
Some point mutations can cause greater changes in proteins because they involve substitutions of amino acids with very different properties (e.g., charge or size), leading to significant alterations in protein structure and function. In contrast, other point mutations may result in amino acid substitutions with similar properties, causing minimal changes to the protein. Additionally, the location of the mutation within the protein sequence can also influence the degree of impact on protein function.
frameshift
frameshift
Frameshift
A point mutation will change only one particular base of the codon, so it will only cause a change in one of the amino acids that will make up the protein. A deletion mutation will completely remove a base- causing a change in every amino acid that follows the deletion. Here is an example with a sentence, using three letter words (since amino acids are determined from 3 letter codons). THE FAT CAT ATE ONE RAT. A point mutation would change only one letter (like changing the C to a B). The new sentence is only slightly changed: THE FAT BAT ATE ONE RAT. A deletion mutation would remove a letter (like deleting the C). The new sentence will now be completely changed from the deletion on. THE FAT ATA TEO NER AT. See the difference??? Point mutations usually take place during DNA replication. A single point mutation can change the whole DNA sequence.
A point mutation will change only one particular base of the codon, so it will only cause a change in one of the amino acids that will make up the protein. A deletion mutation will completely remove a base- causing a change in every amino acid that follows the deletion. Here is an example with a sentence, using three letter words (since amino acids are determined from 3 letter codons). THE FAT CAT ATE ONE RAT. A point mutation would change only one letter (like changing the C to a B). The new sentence is only slightly changed: THE FAT BAT ATE ONE RAT. A deletion mutation would remove a letter (like deleting the C). The new sentence will now be completely changed from the deletion on. THE FAT ATA TEO NER AT. See the difference??? Point mutations usually take place during DNA replication. A single point mutation can change the whole DNA sequence.
Deletion mutations can affect the entire base sequence.
A point mutation will change only one particular base of the codon, so it will only cause a change in one of the amino acids that will make up the protein. A deletion mutation will completely remove a base- causing a change in every amino acid that follows the deletion. Here is an example with a sentence, using three letter words (since amino acids are determined from 3 letter codons). THE FAT CAT ATE ONE RAT. A point mutation would change only one letter (like changing the C to a B). The new sentence is only slightly changed: THE FAT BAT ATE ONE RAT. A deletion mutation would remove a letter (like deleting the C). The new sentence will now be completely changed from the deletion on. THE FAT ATA TEO NER AT. See the difference??? Point mutations usually take place during DNA replication. A single point mutation can change the whole DNA sequence.
A permanent change in the gene's DNA sequence. Gene mutations involving one or a few nuckeotides is called point mutation. If a nucleotide is added or deleted, the bases are still read in groups of three, but now those groupings are shifted for every codon that follows. This is called frameshift mutation. Your welcome. (:
point mutations include substitutions insertions and deletions of a single nuceotide in DNA. CONSIDER: insertions and deletions have a greater effect on proteins that do substiutions because insertions and deletions affect every amino acid that is specified by the nucleotides that follow the point of mutation CONSIDER: a substitution affects a single amino acid a change in more than one amino acid is more likely to alter the ability of the protein to function narmally than is a change in a single amino acid CONSIDER: follow me on twitter @Rocco_Gone_Ham
every amino acid is difined by a set of 3 baces. If you change the amino acids you change the protien.
If a nucleotide pair were to be removed from a gene, it would cause a frameshift mutation. This would alter the reading frame of the gene, leading to a change in the amino acid sequence of the protein encoded by that gene. This could potentially result in a nonfunctional or altered protein.
A mutation within a gene can change the DNA sequence, which can affect the corresponding mRNA sequence. This, in turn, can alter the amino acid sequence of the protein that is produced, potentially changing its structure and function.