Te most important advance towards our understanding of the cellular basis of antibody response was provided by the clone selection theory by Mac Farlane Burnet in 1957.
Clonal selection theory explains how the adaptive immune system selects and amplifies immune cells (such as B cells and T cells) that are specific to antigens. When a pathogen enters the body, immune cells with receptors that match the antigen are selected for activation and proliferation, leading to a targeted immune response. This theory is fundamental to understanding how the immune system responds to infections and develops immunological memory.
Clonal selection is responsible for the production of a large population of identical B or T cells that specifically recognize and target a particular antigen. This process is critical for the adaptive immune system's ability to mount a targeted immune response against pathogens.
Antigen challenge and clonal selection are most likely to occur in the secondary lymphoid organs, such as the lymph nodes and spleen. These organs are where antigens encounter immune cells, triggering an immune response and the selection of specific immune cell clones.
Antigen-presenting cells (APCs) are nonlymphocyte cells that play a central role in clonal selection. They present antigens to T cells, triggering the immune response and selection of specific clones of T cells that can recognize and respond to the antigen.
The clonal selection theory explains how B cells produce antibodies in response to specific antigens. When a B cell encounters its specific antigen, it proliferates and differentiates into plasma cells that secrete antibodies. This theory underlies the adaptive immune response and the specificity of antibody production by B cells.
Evolution by natural selection.
False
Clonal selection is responsible for the production of a large population of identical B or T cells that specifically recognize and target a particular antigen. This process is critical for the adaptive immune system's ability to mount a targeted immune response against pathogens.
Clonal selection and differentiation of lymphocytes provide the basis for immunological memory.
Antigen challenge and clonal selection are most likely to occur in the secondary lymphoid organs, such as the lymph nodes and spleen. These organs are where antigens encounter immune cells, triggering an immune response and the selection of specific immune cell clones.
Antigen-presenting cells (APCs) are nonlymphocyte cells that play a central role in clonal selection. They present antigens to T cells, triggering the immune response and selection of specific clones of T cells that can recognize and respond to the antigen.
The Clonal Selection Theory explain how the immune system can be both diverse and very specific at the same time.The theory states:All antibodies are precommitted to making a single antibody with a single specificityA single cell produces only one antibody which interacts with only one antigen with the highest specificityWhen the right antigen interacts with that cell, it leads to clonal expansion and proliferation of that cell, so that many daughter-cells are made with the exact same specificityThe ability to recognise an antigen is dependent on a receptor, and the receptor is a product of the same cell that secretes the antibody. This ensures that made antibodies will fit with the antigen they are supposed to bind.A clone is defined as a group of cells in which all daughter cells are equal in their specificity
The clonal selection theory explains how B cells produce antibodies in response to specific antigens. When a B cell encounters its specific antigen, it proliferates and differentiates into plasma cells that secrete antibodies. This theory underlies the adaptive immune response and the specificity of antibody production by B cells.
Natural Selection
Darwin's theory of evolution.
Natural selection
Random processes are not part of the theory of evolution by natural selection.
The theory of evolution by means of natural selection.