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"Good's" Buffers refer to the group of buffers described in the research of Dr. Norman Good et al. in 1966. These buffers were selected because they display characteristics making them integral to research in Biology and biochemistry. The characteristics associated with a Good's buffer include the following: pKa value between 6.0 and 8.0, high solubility, non toxic, limited effect on biochemical reactions, very low absorbence between 240 nm and 700 nm, enzymatic and hydrolytic stability, minimal changes due to temperature and concentration, limited effects due to ionic or salt composition of the solution, limited interaction with mineral cations, and limited permeability of biological membranes. (Reference: Good, N.E., et al. (1966) Hydrogen Ion Buffers for Biological Research. Biochemistry 5(2), 467-477.)

Pasted from: http://www.sigmaaldrich.com/catalog/search/TablePage/14572938 "Good's" Buffers refer to the group of buffers described in the research of Dr. Norman Good et al. in 1966. These buffers were selected because they display characteristics making them integral to research in biology and biochemistry. The characteristics associated with a Good's buffer include the following: pKa value between 6.0 and 8.0, high solubility, non toxic, limited effect on biochemical reactions, very low absorbence between 240 nm and 700 nm, enzymatic and hydrolytic stability, minimal changes due to temperature and concentration, limited effects due to ionic or salt composition of the solution, limited interaction with mineral cations, and limited permeability of biological membranes. (Reference: Good, N.E., et al. (1966) Hydrogen Ion Buffers for Biological Research. Biochemistry 5(2), 467-477.)

Pasted from: http://www.sigmaaldrich.com/catalog/search/TablePage/14572938

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A buffer is a solution that helps maintain a stable pH level by resisting changes in acidity or alkalinity. Good buffers are able to efficiently stabilize pH within a specific range, which is important for many biochemical and chemical reactions to occur optimally. Buffers are commonly used in laboratory settings, as well as in various industrial processes and environmental applications.

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What is the most important buffer in extracellular fluids?

The bicarbonate buffer system is the most important buffer in extracellular fluids, including blood. It helps maintain the pH level of the body within a narrow range by regulating the levels of bicarbonate ions and carbonic acid.


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The bicarbonate buffering system typically acts the fastest among the body's buffer systems. This system helps regulate the pH of the blood by quickly reacting with excess hydrogen ions to maintain a stable pH.


Which buffer system is the most abundant in the body?

The bicarbonate buffer system is the most abundant buffer system in the body. It helps regulate pH in the blood by maintaining a balance between carbonic acid (H2CO3) and bicarbonate ions (HCO3-).

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