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If the gene is obscured and hidden by folds or heavily methylated, RNA polymerase has a difficult time getting to the promoter region to initiate transcription. If the polymerase can't get there, then the gene is not transcribed and translated to a protein.

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Dense packing of DNA in chromosomes can hinder gene expression by physically limiting the access of transcription factors to the gene sequences. This compact structure can also prevent the necessary regulatory proteins from binding to specific gene regions, thereby impeding the initiation of transcription. Additionally, the condensed chromatin can restrict the movement of RNA polymerase along the DNA, further inhibiting gene expression.

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Q: How does dense packing of DNA in chromosome prevent gene expression?
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