To prevent the fatigue you have to reduce the amount of driving time. On a long distance the best way to avoid the fatigue is driving no more then eight hours in the row.
a good night sleep
Coffee . Smoke a big cigar.
how does fatigue effect your driving
Pull over every 2 hours for five min to have a stretch. It can be a pee break or something.
You should drink lots of cold ice water and do not over do the activity.
Yes fatigue is considered an impairmrnt it affects your driving just as well as alcohol or drugs
rest
fatigue
A driver should take a break when he/she is fatigued. It is recommended that a driver take a break every 2 hrs
UK law for commercial drivers. You must take a 45 minute break after 4 1/2 hours driving/working time
I'm not going to say you should, however this will help to fight fatigue. By the way it should never be turned up so loud that you could not hear a horn or a siren.