The driving distance from Austin, TX to Santa Fe, NM is 690 miles.
700 miles on I-84 E.
Stephen Austin was in Texas. He did not travel the Santa Fe Trail.
Santa Fe, NM about 19.5 hours Santa Fe, TX about 6.25 hours
The driving distance between Denver, CO and Santa Fe, NM is 395 miles. The driving time would be approximately 6 hours 15 minutes if driving non-stop in good conditions. (The driving time does not take into consideration conditions such as weather, road work and rush hour traffic in urban areas.)
The approximate driving time and mileage information - Between: Santa Fe, NM and: Austin, TX Driving miles: 690 Driving time: 11 hrs 15 mins - is based on traveling non-stop in good driving conditions. Driving time does not take into consideration conditions which may extend travel time such as weather, road work, border crossings, and rush hour traffic in urban areas. Mileage denotes actual road miles covered as opposed to Point A to Point B linear distances on a map.
From Tampa, FL to Santa Fe, NM is 1,904 miles; approximately 29 hours driving time.
From Austin, you would travel north to intersect with the Santa Fe Trail, and then go west to Santa Fe. There may have been other trails that went more directly northwest.
The driving distance from Prescott, Arizona to Santa Fe, New Mexico is 478 miles via I-40 E per MapQuest. The driving time per MapQuest is 7 hours.
The route with the shortest driving time is about 360 miles.
That would depend a great deal on where you're coming from.
Austin