The distance from Tuscaloosa, Alabama to Tyler, Texas is 498.56 miles. The time it would take to get there would be 7 hours and 32 minutes. You would just take I-20 WEST. To bypass Shreveport, take I-220 WEST - BYPASS. (EXIT 26 off I-20 in Louisiana, then EXIT 1B off I-220 - BYPASS to get back onto I-20 WEST).
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