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695 miles taking this route:

  1. Take I-85 SOUTH, from Thomasville, to I-77 SOUTH to COLUMBIA at EXIT 38, in Charlotte.
  2. Take I-77 SOUTH to I-26 EAST to CHARLESTON (to I-95), at END I-77 in Columbia, South Carolina.
  3. Take I-26 EAST to I-95 SOUTH to SAVANNAH at EXIT 169A.
  4. Take I-95 SOUTH to I-10 WEST to LAKE CITY, via I-295 WEST BELTWAY (FL) to bypass JACKSONVILLE, FL (EXIT 362B off I-295 to get onto I-295 WEST BELTWAY ; EXIT 21B off I-295 to get onto I-10 WEST to LAKE CITY).
  5. Take I-10 WEST to I-75 SOUTH to TAMPA at EXIT 296A, near Lake City.
  6. Take I-75 SOUTH to Tampa. To get to the city itself, take I-275 SOUTH (EXIT 274 off I-75 to get onto I-275 SOUTH to TAMPA and ST. PETERSBURG).
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Q: What is the distance between Thomasville NC and Tampa Fla?
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