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By taking 285 South to Clines Corners you can save both time and mileage as well as avoiding the Albuquerque traffic congestion. At Clines Corners you pick up I-40 and the trip to Amarillo will have covered only 279.86 miles and will require an estimated 4 hours and 12 minutes of driving time. Via Albuquerque you add at least an extra hour of driving and an extra 75 miles.

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Q: What is the distance between Santa Fe and Amarillo?
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