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About 502.30 miles according to MapQuest.
510 miles taking this route:

  1. Take I-5 NORTH from San Diego to I-580 WEST to San Francisco at EXIT 446, near Tracy. To bypass LOS ANGELES, take I-405 NORTH (EXIT 94 off I-5).
  2. Take I-580 WEST to I-80 WEST to SAN FRANCISCO at EXIT 19A in OAKLAND.
  3. Take I-80 WEST to SAN FRANCISCO via the BAY BRIDGE (toll bridge).
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Q: What is the distance between San Diego CA and San Francisco CA?
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Related questions

How many miles between san Diego and san francisco California?

550 miles http://www.hm-usa.com/distance/ca.html


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