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1,000 miles taking this route:

  1. Take I-40 EAST from Memphis to I-81 NORTH to BRISTOL at EXIT 421. To bypass downtown Nashville, take I-440 EAST (EXIT 206 off I-40 in Tennessee). To bypass downtown Knoxville, take I-640 EAST (EXIT 385 off I-40).
  2. Take I-81 NORTH to I-70 EAST to FREDERICK at EXIT 4A in Maryland near Hagerstown.
  3. Take I-70 EAST to I-95 NORTH to NEW YORK via I-695 NORTH around Baltimore (EXIT 91B off I-70 to get onto I-695 NORTH; EXIT 33B off I-695 to get onto I-95 NORTH to NEW YORK).
  4. Take I-95 NORTH to New Castle.

The half-way point is Bristol. I would highly recommend you to stay here overnight.

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Q: What is the distance between Memphis TN and New Castle DE?
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