the shortest air route is a great circle
The distance from Baltimore, MD to Myrtle Beach, SC is about 487.2 miles (according to the shortest route on Mapquest).
wormhole
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It appears that the Shortest route I can find is from Jacksonville Beach, FL to San Diego, CA, at a distance of 2,109 miles according to Google Maps.
The shortest route between 2 points on the surface of a planet is a great circle route, which is a path that follows the circumference of a circle formed by the intersection of the planet's surface and a plane passing through its center. This route represents the shortest distance between the two points.
The driving distance from Delray Beach, FL to Naples, FL is approximately 140 miles and takes about 2.5 to 3 hours depending on traffic and route taken.
Great Circle Route
Shortest route is 18 hours 59 minutes long
The route with the shortest driving time is about 115 miles.
The quickest route in regards to the shortest number of miles driven can be found on Mapquest.
The route with the shortest driving time is about 19 miles.