About 300 miles
293 miles down I-55 SOUTH.
Yes, St. Louis, MO is southwest of Chicago, IL.
It is 505 kilometers according to Google Maps.
It is 299 miles according to Google Maps.
The distance between St. Louis and Columbus is 424 miles.
Chicago.
St Louis Il is across the river from St Louis MO
East St. Louis is actually in Illinois.
Milwaukee is about 85 miles farther away then Chicago.
Illinois River
297 miles.