1,050 miles taking this route:
how many miles from Savannah, GA to Hilton Head, SC
288 miles
254 miles
318.6 miles
281 miles
About 2800 miles
201 miles
about 650 miles
From Saint Louis, Missouri to Hilton Head Island, South Carolina it is 838 miles.
The driving distance between Hilton Head, SC and Knoxville, TN is approximately 400-425 miles, depending on the route taken.
492 miles
It is 253 miles according to Google Maps.