Take U.S. 51 SOUTH towards DYERSBURG from Newbern to U.S. 412 EAST (TO I-40) to JACKSON at the NEXT EXIT.
Take U.S. 412 EAST to I-40 in Jackson. Turn left onto the on-ramp to I-40 EAST.
Take I-40 EAST all the way across to TN-66 to GATLINBURG SEVIERVILLE and PIGEON FORGE at EXIT 407. To bypass downtown Nashville, take I-440 EAST (EXIT 206 off I-40). To bypass downtown KNOXVILLE, take I-640 EAST (EXIT 385 off I-40).
Turn right off the exit ramp and take TN-66 SOUTH to U.S. 441 SOUTH to GATLINBURG and PIGEON FORGE. Continue STRAIGHT on U.S. 441 SOUTH to Gatlinburg.