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The driving distance between Louisville, KY and St. Louis, MO is approximately 265 miles. The driving time would be approximately 4 hours 30 minutes if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work and rush hour traffic in urban areas.)

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Q: How long does it take to drive from louisville to st Louis?
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