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- Take I-24 EAST from Clarksville to I-40 EAST to KNOXVILLE via TN-155 - BRILEY PKWY EAST and, eventually, SOUTH. (EXIT 43 off I-24 to get onto TN-155 - BRILEY PKWY; EXIT 6B off TN-155 - BRILEY PKWY to get onto I-40 EAST.)
- Take I-40 EAST to U.S. 321 NORTH in Hickory, North Carolina.
- Take U.S. 321 NORTH to Boone.
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