Not far, depending on where you are in Winston-Salem (large city) it would be anywhere from 3 minutes to 20 minutes.
45 miles
80 miles
500 miles
73 miles
50 miles
516 miles
36 miles
117 miles taking this route:Take NC-87 NORTH from Fayetteville to U.S. 421 NORTH in Sanford.Take U.S. 421 NORTH to I-40 WEST to WINSTON-SALEM near Greensboro.Take I-40 WEST to Winston-Salem.
It is 122 miles according to Google Maps.
105 miles
80.5 miles according to Mapquest