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  1. Take I-79 NORTH to I-80 EAST to CLARION at EXIT 116A.
  2. Take I-80 EAST to I-81 NORTH to WILKES-BARRE and SCRANTON at EXIT 260B (LEFT EXIT).
  3. Take I-81 NORTH to Wilkes-Barre.

You can remember the route by just thinking 79 80 81.

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Q: Directions from Pittsburgh to Wilkes barre?
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