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Generally, in space, astronauts & cosmonauts are in a constant state of free fall--the same feeling when you go down a large hill in a roller coaster--but for several hours/days/weeks/months.

So primarily, motion sickness.

But also, the human circulatory systems has evolved to exist with gravity. In orbit, these mechanisms malfunction, and fluid tends to accumulate in the head--causing puffy eyes and faces.

Typically, people adjust to these changes in a day or two. Some unfortunate people never adapt, and have a miserable time in space.

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Q: What causes space sickness?
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