Generally, in space, astronauts & cosmonauts are in a constant state of free fall--the same feeling when you go down a large hill in a roller coaster--but for several hours/days/weeks/months.
So primarily, motion sickness.
But also, the human circulatory systems has evolved to exist with gravity. In orbit, these mechanisms malfunction, and fluid tends to accumulate in the head--causing puffy eyes and faces.
Typically, people adjust to these changes in a day or two. Some unfortunate people never adapt, and have a miserable time in space.
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In space, there is no atmosphere to equalize pressure, so any air or gas inside an astronaut's body expands and causes the body to "blow up" or swell. This is known as decompression sickness or the "bends," and it can be dangerous or even fatal. Proper pressurized spacesuits are used to protect astronauts when in space to prevent this from happening.
Astronauts are important because they advance our knowledge on space, and space exploration. They find cures for diseases or sickness's such as bone cancer or motion sickness. They can also tell what the temperature or weather is. They can also report to other countries if something bad is coming toward them like, a worldwide flood.
Yup. Its not uncommon to experience space sickness for the first day or two in space. Some people never adapt (see Jake Garn).
Space suits are necessary for astronauts to survive in the harsh environment of space. They provide protection against extreme temperatures, radiation, and the vacuum of space. They also supply oxygen for breathing and regulate internal pressure to prevent decompression sickness.
Fred Haise experienced Space Adaptation Sickness, a condition similar to motion sickness and caused by gravitational changes affecting the body's spatial orientation.