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During takeoff, an astronaut may feel intense acceleration forces pushing them back into their seat, similar to experiencing the force of gravity multiplied several times. They may feel pressure and vibration as the rocket engines ignite and propel the spacecraft into space, causing their body to physically react to the G-forces. The experience can be exhilarating and overwhelming as the spacecraft accelerates rapidly towards orbit.
Explosion.
Gus Grissom was the Mercury astronaut who had a pulse rate of 170 at lift off. This high pulse rate was of concern to the mission controllers.
If an astronaut were to take off their helmet in space, they would be exposed to the vacuum of space which would lead to decompression, causing rapid loss of consciousness within a few seconds. Due to the lack of oxygen, the astronaut would ultimately suffocate and die.
If an astronaut took off his helmet in space, his body would explode from the lack of pressure in space before other problems would become noticeable.
The space shuttle experienced about 3 g's of acceleration during takeoff.