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It is impossible to point to one single work as the most significant.

Works of each of the the leading Italian Renaissance painters compete about this title.

Leonardo: Mona Lisa, the Last Supper. Adoration of the Magi.

Michelangelo: Sistine Chapel murals, David. The Last Judgment.

Raphael: School of Athens mural, Sistine Madonna.The Alba Madonna.

The compting works were done in Rome (papal commissions) and Florence.

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Q: Where was the most significant work being done in the High Renaissance and why?
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