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Rome, Florence and Tuscany.
Florence was one of the influential cities when talking about art. That was where the Medici family was, so there was a lot of art and sculpting going on.
most readers had not been to those cities
Well, the Renaissance movement in general was started in Italy, by many famous artists in the 15th-16th century. Cities would hire and/or support these artists. After the Renaissance movement started in Italy, many other European countries started to follow it, which led to more artistic and cultural improvements, aswell as an increase in the number of known artists.
Most readers had not been there yet