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What protein concentration controls beginning and end of interphase?
Cyclin
What questions might scientists have asked following the discovery of cyclin?
Scientists might have asked how cyclin levels are regulated during the cell cycle, what specific role cyclin plays in regulating cell division, and whether abnormalities in cyclin expression or function are associated with diseases like cancer.
What causes the decrease in the amount of cyclin at a specific point in the cell cycle?
The decrease in cyclin levels at a specific point in the cell cycle is typically caused by the cyclin being targeted for degradation by ubiquitin-mediated proteolysis. This process is regulated by the activity of specific enzymes called ubiquitin ligases, which mark the cyclin for destruction by the proteasome. This decrease in cyclin levels is important for progression to the next phase of the cell cycle.
What is a cyclin and what does it activate?
Cyclins are proteins that regulate the cell cycle by binding to cyclin-dependent kinases (CDKs). This binding activates the CDKs, leading to the phosphorylation of target proteins that drive the cell cycle progression.
How does cyclin dependent kinase work?
Cyclin dependent kinases (CDKs) are a family of enzymes that regulate cell cycle progression by phosphorylating target proteins involved in cell division. CDK activity is tightly regulated by the binding of cyclins, which activate their kinase function. CDK-cyclin complexes phosphorylate key proteins to drive cell cycle transitions.
What causes the MPF complex to initiate mitosis in the cell cycle?
The MPF complex is activated by the phosphorylation of its Cyclin B subunit by Cyclin-dependent kinase (Cdk), causing the complex to become active and initiate mitosis. This phosphorylation is regulated by various factors such as growth factors, DNA damage, and regulatory proteins within the cell cycle.
Where can you buy cyclin from?
Well dah!!! Were everyone else gets cyclin from the cyclin store!
Describe the relative concentrations of MPF and its constituent molecules throughout the cell cycle?
During the cell cycle, the concentration of MPF (M phase promoting factor) is low during interphase and increases as cells approach the G2 phase. MPF is composed of cyclin B and Cdk1. Cyclin B concentration increases in the late G2 phase, leading to the activation of Cdk1 and the formation of active MPF, which initiates mitosis.
Is eukaryotic cells the timing of the cell cycle regulated by cyclins?
Yes, in eukaryotic cells, the timing of the cell cycle is regulated by cyclins. Cyclins are proteins that control the progression of the cell cycle by activating cyclin-dependent kinases (CDKs). The levels of different cyclins fluctuate throughout the cell cycle, signaling the cell to move from one phase to another.
The extracellular fluid concentration of which ion is not primarily regulated by the kidney?
iron
How is the amount of water in each body compartment regulated?
Electrolyte concentration
Eplain how mpf induces the changes that occur in mitosis and describe what causes the cyclical change in mpf concentration?
MPF, or maturation-promoting factor, induces the changes in mitosis by promoting entry into and progression through mitosis. It is mainly composed of cyclin-dependent kinase and cyclin. The cyclical change in MPF concentration is caused by the periodic synthesis and degradation of cyclin, which activates the kinase activity of the cyclin-dependent kinase and regulates the progression of the cell cycle.
