The last series was dated 1934.
See : http://moneyfactory.gov/100002greendenom.html
Dan Moore
The Working Man's Rare Coins
http://www.workingmancoins.com
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The last year that they printed any high denomination currency was in 1945 (with the series of 1934). They started being actively removed from circulation starting in 1969 (although in practice most had vanished earlier) and today they are worth more than face to collectors of currency (especially the 10,000 bill!)
Coins are minted, bills are printed.$2 bills are still being made, just not in very large quantities. As of this writing, the most recent series was started in 2013.
In the United States of America, the Secretary of Treasury that is in office at the time the paper currency is printed is whose signature appears on the actual bill. It is the same signature used for all currency values: $1, $2, $5, $10, etc. Therefore, the signature will vary from year to year based on who actually held that office the year that the currency was printed.
february 18, 1996
They're printed every year.