No.
Open the trunk. Loosen the black thumb latch wing nuts that hold the tail light assembly in place. pull the tail light assembly out. You should be able to acces the tail light bulbs to replace them.
Take the light assy off.
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Look in the trunk, there is a cover over the light assembly - open and you will have access to change the light.
http://laudeman.com/volkswagen/index.html has a great step by step on how to do it.
how to change tail light bulb on Toyota sequoia
How do you change the tail light on a 2001 toyota sequoia
I'm pretty sure it will.
You will have to get in the trunk pull a couple clips off that hold the carpet over the back side of you tail lights. There are 3 nuts that hold the light assembly to the car. Unscrew those and then the tail light will come out ( you have to kind of angle it). There are bulbs you will have to twist the wiring clips for the out of the tail light.
See Tail/Stop/Turn Signal and Sidemarker Lamps on page 6-38 of your "Owner's Manual", under Section 6: Service and Appearance Care - Bulb replacement...
on the tail light problem - unbolt the tail light from inside th truck -the hold tail light assemble will come out - it is recommended to change all the blubs your all ready there