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i assume you're asking why it happens. opiates (like oxycodone) are direct mast cell degranulators. the mast cells 'degranulate' and release histamine which makes you itch. usually benadryl (or other antihistamines) help the itching, but be careful when combining sedatives...
It actually is pretty likely but there's plenty of chance that it won't.
Benadryl might help with the itch.
If oxycodone makes you itch from head to toe, it means you are allergic to the medicine or one of the compounds in the pill.
It sounds like you are having an allergic reaction. Discontinue use and call your doctor.
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