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i assume you're asking why it happens. opiates (like oxycodone) are direct mast cell degranulators. the mast cells 'degranulate' and release histamine which makes you itch. usually benadryl (or other antihistamines) help the itching, but be careful when combining sedatives...

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16y ago

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More answers

It actually is pretty likely but there's plenty of chance that it won't.

Benadryl might help with the itch.

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Wiki User

15y ago
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If oxycodone makes you itch from head to toe, it means you are allergic to the medicine or one of the compounds in the pill.

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Wiki User

14y ago
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It sounds like you are having an allergic reaction. Discontinue use and call your doctor.

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Wiki User

14y ago
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nope that's normal

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Wiki User

13y ago
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Q: Can oxycodone cause itchy rashes
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