It's a niche product and constantly changes. The MARVEL MASTERPIECES holographic cards are usually fairly high (if you exclude plates and autographed). It also depends if you're refering to series such as "The Lone Ranger" or "Batman" cards. Go to the library and look into a non-sport card buyers guide. It will give you a more accurate answer.
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The most expensive comic card is the 1938 #1 Action Comics, which features the first appearance of Superman. In 2014, a near-mint copy of this comic sold for over $3.2 million at auction, making it the most expensive comic book ever sold.
The 90s was a comic book graveyard. So much volume. Such spotty quality. That said, very generically, I would say Bone #1 is the most valuable depending on condition.
Action Comics # 1 which is the first appearance of Superman and sells for no less than a $ 100,000 .