An underlying condition is one that, on its face, may appear to be unrelated to the condition being studied, but may affect the condition. A common example: anemia is considered differently when an underlying condition of pregnancy is present. Excessive sweating is worked up differently in the case when opiate addiction is an underlying condition. Fever workup is different if there is an underlying immunological condition.
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An underlying condition refers to a pre-existing medical condition that exists before the onset of a new or acute condition. It can affect the course and treatment of the new condition. Examples include Diabetes, Heart disease, and Asthma.