This depends on the size and age of the dog. First time mothers will have smaller litters, for German Shepherds, probably 7 to 9 puppies.
Maybe if in a really humid environment, but generally German Shepherds are healthy... Some of its health problems develop due to old age...
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When they become sexually mature but a female should always miss her first.
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The average age for a first heat cycle is around 6 months of age. Although, larger breeds can have their first heat stage as late as 18 mths.
It depends on the breed and weight of the heifer, but I have seen Holsteins as young as 6 months in heat. However, this is not a recommended age to begin breeding.
It depends on her age and size when she has her first 'heat' normally it is best to wait until she is 10 to 12 months old.
Both genders are fertile all of their life, A female shouldn't breed after the age of seven though.
When they are sexually mature.
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Staffied come into heat for the first time at around 6 months of age, but it is recommended that you wait until the second heat before breeding the dog, preferably at least one year of age.