Niacin, or vitamin B3 occurs in most grains, especially whole grains. Severe deficiency of niacin (which is usually associated with malnutrition, or starvation) causes the disease pellagra. The main symptoms of untreated pellagra are the "4 D's": Diahrrea, dermatitis (red sores or itching), dementia and death. In previous generations, niacin was sometimes called Vitamin PP (for Prevents Pellagra.) The body can create niacin from tryptophan, an amino acid that occurs in milk and meat. People who eat little protein have an increased need for niacin. Many people believe that a mild niacin deficiency slows the metabolism and decreases tolerance to cold. The daily requirement for niacin ranges from 12mg in children to 18 mg in pregnant and nursing women. Niacin defiencies tend to occur only in areas where people eat corn (or maize) instead of wheat, rye or other grains. That's because corn contains niacin in a form the body cannot use. When corn meal or flour is processed with lime, it releases the niacin. One way to prevent a niacin deficiency is to take a daily multi-vitamin and eat a balanced diet including whole grains and poultry, milk, meat, and eggs.
Niacin deficiency can be treated effectively with replacement of niacin in the diet. In the case of Hartnup disease, large quantities of niacin may be required for effective reversal of symptoms.
Diagnosis is based on the patient's symptoms and information about their diet. When this information points to niacin deficiency, replacement is started. There are no chemical tests available.
It is due to the deficiency of Vitamin B3 (Niacin)
A niacin or vitamin b3 deficiency.
Pellagra is a Vitamin B3 (Niacin) deficiency disease. It is caused by severe and prolonged deficiency of Vitamin B3. Symptoms are bilateral dermatitis, dementia, and diarrhea. A prolonged and severe niacin deficiency may cause depression and neurasthenia (weakening of muscles).A deficiency in Vitamin B3 can cause depression, memory loss, canker sores and fatigue.
When you don't get enough niacin (vitamin B3), it can lead to a deficiency known as pellagra. Symptoms of pellagra include dermatitis, diarrhea, dementia, and, if left untreated, can be fatal. Niacin is essential for energy metabolism and the health of the skin, digestive system, and nervous system. A deficiency is often associated with inadequate dietary intake, chronic alcoholism, or certain medical conditions.
Niacin deficiency produces pellagra characterized by diarrhea, skin rashes, brain dysfunction, tongue, mouth and vaginal irritation, and trouble swallowing.
"Symptoms of mild deficiency include indigestion, fatigue, canker sores, vomiting, and depression. Severe deficiency can cause a condition known as pellagra. Pellagra is characterized by cracked, scaly skin, dementia, and diarrhea. It is generally treated with a nutritionally balanced diet and niacin supplements. Niacin deficiency also results in burning in the mouth and a swollen, bright red tongue."
Rickets in children and osteomalacia are examples of deficiency diseases due to vitamin deficiency. Scurvy is an example of vitamin C deficiency. Beriberi is an example of vitamin B one deficiency. (Both, wet beriberi and dry beriberi.) Pellagra is an example of Niacin deficiency. Anemia is caused by deficiency of vitamin B 12 and Folic acid. Burning feet syndrome is caused by the deficiency of Pantothenic acid. Night blindness is caused by the deficiency of vitamin A. Kwashiorkor and marasmus are caused by deficiency of proteins and food, respectively. Poverty is caused by deficiency of kindness. Inequality is caused by deficiency of compassion.
A deficiency disease is one caused by a lack of something we need. Some examples are:scurvy, caused by insufficient vitamin C. Symptoms include bleeding gums and failure to heal.rickets, caused by lack of calcium or vitamin D. Symptoms are weak, soft bones and stunted growth.Pellagra, caused by lack of vitamin B3, niacin. Symptoms include inflamed skin, diarrhea, dementia, and sores in the mouth.
Pellagra
In a terse manner, Niacin (B3) is used in the human body to form coenzymes NAD and NADP - two very important components that are involved in energy production. Pellagra is the main deficiency of Niacin.