The best course to take, is the one you have a passion for and leads to your overall career goals and objectives. You need to get a vision; a clearly articulated picture of the future you intend to create for yourself. It's a dream. Once you have this, the rest will become apparent. That is, you will have to develop a road-map leading to your overall career objective. The rest is 100% commitment.
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There isn't a single "best course" for everyone - I really enjoyed chemistry, but plenty of people who struggle with math would hate this. Others enjoy creative writing or history, which bores the bejeezus out of me.
The better question to ask is, what would be the best course for me to pursue in college? To answer this, I would suggest starting with what you enjoyed from high school - what classes interested you? Also, what fires you up and gets you passionate about doing something? The answers to these two questions should lead you to a career path of some sort - from there, investigate the options and (honestly) weigh the financial implications - how much will college cost and how much will you make? Are there jobs doing this available now, and how many jobs will be available when you graduate?
Determining what course you like best will help you when it comes to selecting a job. When you have a passion about something, you wouldn't mind doing it for the rest of your life.
The best classes to take at a university are the ones that will benefit you the most. These classes should suit one's interest and help them progress in the future.