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These two products are different, and they kill with different mechanisms. RoundUp (glyphosate) kills pretty much all vegetation and Crossbow is a combination of two broadleaf killers, which are ester 2,4,-d and triclopyr. RoundUp may be "stronger" in a sense but if you are targeting particular weeds with the desire to keep the grass around, use Crossbow.

One thing to keep in mind is that if you kill everything using RoundUp, you're opening your ground to a whole host of other weeds that will move in as soon as the RoundUp binds with the soil (RoundUp doesn't go away, it just binds very readily with soil and organic particles). Nature abhors a vacuum so in many cases it's better to hit the thistles and woody weeds with the Crossbow and allow grass to take over. Otherwise you can end up with even more thistles and plants you would have never imagined coming in six months later.

Crossbow and any other broad-leaf killer works most effectively on actively-growing plants except some respond better when hit in the fall. Same deal with RoundUp. Crossbow may be more likely to make its way through the soil to kill plants you didn't mean to kill. RoundUp stays where you spray it, even after it hits the soil.

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Q: Round-Up versus Crossbow herbicide - which is stronger?
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