This vary from apple to apple, and also very much between the type of apple.
Most apples have between 8-12 seeds, but some have less, others have many many more.
The amount of seeds may vary with the condition of the tree, and the growth year also. If it is a particularily bad year, then there might be more seeds and fewer apples. In a good year, the apples will be bigger and have fewer seeds.
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Apple seeds contain cyanide.
Cyanide has an LD50 of 8 mg/kg, this means that in a sample of laboratory rats, when the level of cyanide reaches 8mg/ kg of body weight (or 50 parts per million) 50% of the sample population can expected to die. This is the way that toxicity of a substance is calculated.
This means that an individual weighing 50kg will have to ingest 400mg of cyanide in order to kill them (50% chance).
The other issue to bear in mind is that apple seeds only contain a small amount of cyanide, so you would have to eat a lot of them to make you sick.
People have differing metabolic rates, this could also effect how cyanide is processed by the body and how toxic it may be to a person.
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189. Use 131 of them to close his/her throat and then put 29 seeds in each nostril