Dr. John Smith
Dr. Mary Brown if they are at the same address, of different genders and not married.
Dr. John Smith & Dr. Mary Brown if they are at the same address and married but not using the same last name.
Drs. John & Mary Smith if they are married and using the same last name
Dr. John Smith
Dr, Fred Brown if they are at the same address of the same gender and not married.
The progression is the same as above if they are married.
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To address an envelope to two or more doctors, you'd write:
Doctors [Smith] and [Jones] or
Doctors [Smith, Jones] and [Brown],
and so on.
You could also abbreviate 'Doctors' and write:
Drs. [Smith and Jones],
Beginning a letter to two or more doctors, you'd start with:
Dear Doctor [Smith] and Doctor [Jones], and so on.
It's really a matter of personal preference, theirs and yours. If you want to be sure of getting it right the best thing to do is ring their office and ask a staff member how they prefer to be addressed on envelopes and in letters. Some people don't care how they're addressed, but some do, and some set great store by it, so it's always good manners to be correct.