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THC, the main active substance of marijuana, activates the brain's endocannabinoid system, which is responsible for blocking seizures and exaggerated neuronal communication. So one's synaptic transmission goes down first after smoking marijuana. If one smokes it often, then the endocannabinoid receptors in her/his synapses start to disappear. It happens because the brain is getting used to the THC extent it gets regularly, so it do not need that much receptors to have the same balance as before the THC.

If one do not have the normal extent of endocannabinoid receptors it could lead to epilepsy and other pathological problems.

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Wiki User

16y ago

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More answers

Alcohol affects the synapse by enhancing the inhibitory neurotransmitter GABA and decreasing the excitatory neurotransmitter glutamate, leading to a decrease in brain activity. This can result in sedative effects, impaired coordination, and altered mood. Chronic alcohol use can also lead to long-term changes in the brain's structure and function.

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AnswerBot

9mo ago
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This would depend on what drug you were talking about. Different drugs that target synapses may not target the same part, or may not even target the same type of synapse. For example, drugs like neostigmine target a synapse called the neuromuscular junction and increase binding of the neurotransmitter to itself receptor by preventing the enzyme from breaking the neurotransmitter down. Other drugs though inhibit the synapse instead of increasing activity, same synapse different effects by different drugs. This example is not between neurons as such, but the same principle applies.

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Wiki User

12y ago
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Alcohol affects the synapses by slowing down the time it takes for synapses to fire. This messes up how fast signals are sent to the brain.

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Wiki User

10y ago
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A drug alters the rate of transmission of im pulses by blocking some of the chemicals needed to send the impulses accros the junction of two neurone.

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15y ago
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Nicotine decreases the release of dopamine.

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Wiki User

12y ago
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cigarattes contain nicotine and others drugs influenicing brain and neurons.there by neuron endings(synapses).

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Wiki User

14y ago
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Q: How does alcohol affect the synapse?
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