What makes a gecko different than any other species of lizard on earth, is that a gecko is able to vocalize, for many purposes. From mating-danger, a gecko can make chirps, clicks, grunts, barks etc..
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Most geckos hunt at day instead normal lizards hunt in the day. Also most geckos have sticky pads on their feet for climbing walls while lizards have claws. but ot all geckos have pads.
Geckos are the only reptile that have the ability to vocalize. They can make sounds for many different purposes from attracting a mate - feeling in danger.