If you're referring to the holy place of worship for Muslims, this building is called a mosque. If you are talking about the building around which Muslims travel around seven times on pilgrimage, this is called the Ka'abah, and was built by Ibrahim.
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It is either:
Masjid Al-Haram in Makkah Al-Mukarramah
followed by
Masjid Al-Nabawi in Al-Madina Al-Munawwara
Kaaba in Makkah (Mecca) in Saudia Arabia. Refer to questions below for more information.
The holy building where the Muslims pray is called: mosque- Masjid.
The Ka'aba is the most sacred place of the Muslims where they perform Hajj.